This article, which appeared the other day in the Journal of Nutrition shows that high-dose CoQ10 impaired cognitive function in mice and had no effect on increasing life-span. One wonders if idebenone suffers the same drawbacks.
Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice.
J Nutr. 2009 Aug 26.
Sumien N, Heinrich KR, Shetty RA, Sohal [...]

In this study, senescent-prone rats were subjected to melatonin between 1 and 10 months of age and their brains investigated for signs of mitochondrial aging. The very promising result for those currently supplementing or planning to supplement with melatonin was that Melatonin administration between 1 and 10 months of age completely prevented the mitochondrial impairment, [...]

A new article in the FASEB Journal shows that resistance to protein folding damage is a clue to longevity in mammals.
Scientists from Texas are batty over a new discovery which could lead to the single most important medical breakthrough in human history—significantly longer lifespans. The discovery, featured on the cover of the July 2009 print [...]

Salk Institute researchers have identified an enzyme crucial to the life-extension effects brought about by dietary restriction. This brings us closer to identifying the initiating signal for the cascade of effects organisms experience when subject to CR conditions. Once this ‘holy grail’ is discovered, we’ll be well on the path to creating a drug that [...]

According to this press release, applying a fluorouracil-containing cream to the skin results in the reduction of the signs of aging. It works essentially by causing superficial damage, which the body then reacts to, healing wrinkles and age spots in the process. The mechanism seems to be similar to that of laser resurfacing.
Topical application of [...]

Wistar Institute team finds key target of aging regulator
Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.
Scientists have [...]

Think memory worsens with age? Then yours probably will…
Thinking your memory will get worse as you get older may actually be a self-fulfilling prophecy. Researchers at North Carolina State University have found that senior citizens who think older people should perform poorly on tests of memory actually score much worse than seniors who do not [...]

Longer life is accompanied by fewer degenerative diseases…
A biochemical pathway that helps keep cells alive when oxygen is low also plays a role in longevity and resistance against some diseases of old age, according to a report to be published April 16 in the journal Science.
A cell’s protective reaction to a drop in oxygen is [...]

Scientists at the Buck Institute for Age Research have identified a protein that plays a key role in the life-extending effects of calorie restriction.
Press release follows:
Buck scientists identify a key protein that may explain the anti-aging and anti-cancer benefits of dietary restriction
Novato, CA, May 21, 2009. A protein that plays a key role in [...]

A little over a month ago I conducted a personal experiment where I took 25mg/day doxycycline hyclate in an effort to improve the quality of my skin by reducing collagen breakdown via the inhibition of Matrix-Metalloproteinases (MMPs).
For the duration of the experiment, I consumed approximately 25mg doxycycline in the morning on top of my usual [...]