‘Aging’ Archive

Green tea mitigates hippocampal aging

More evidence regarding the benefits of green tea consumption:
Chronic green tea consumption prevents age-related changes in rat hippocampal formation.
Neurobiol Aging. 2009 May 1.
Assunção M, Santos-Marques MJ, Carvalho F, Lukoyanov NV, Andrade JP.
Department of Anatomy, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
The hippocampal formation undergoes considerable structural and functional modifications [...]

Anti-inflammatory drugs retard brain aging

This article from Neurobiological Aging reports that users of anti-inflammatory drugs not only have a reduced incidence of Alzheimer’s disease, but also show significantly less age-related brain atrophy, suggesting inflammation may be one of the causes of the cognitive decline commonly seen in the elderly.
Examples of anti-inflammatory substances include the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such [...]

Personal doxycycline hyclate skin experiment

Some of you may be aware that the the antibiotic doxycycline hyclate has been found to possess anti-matrix metalloproteinase (MMP) activities. MMPs are the enzymes that break down connective tissue such as collagen, and their relative increase is thought to contribute to the development of wrinkles in aged skin.
This is because, while the ability to [...]

End to rate-of-living theory of longevity

You might have, at some stage, encountered the idea that the lifespan of an animal is related to its rate of energy consumption; i.e., that the faster its metabolism, the shorter an animal lives. I’ve also heard it said that all animals get a certain number of heartbeats in life and the sooner they use [...]

Yeast, NuA4, Pck1p -> life extension

A press release appeared on the John Hopkins website detailing a new discovery regarding life extension in yeast. The press release can be found here: Starve a yeast, sweeten its lifespan.
To summarize, here’s what happened:

Yeast produce an enzyme complex called NuA4, which is under investigation for its DNA-repair properties.

John Hopkins researchers tested whether NuA4’s level [...]

Mouse study suggests new anti-aging modality

I came across this article today titled “Disruption of the Ang II type 1 receptor promotes longevity in mice”, which is available for free in PDF form for those interested in having a look.
Essentially, the researchers examined the effect of knocking out the Angiotensin (Ang) II type 1 receptor in a bunch of mice and [...]

Smoking and UV exposure reduce melanoma risk

In a strange twist, researchers from the Sunlight, Nutrition, and Health Research Center (SUNARC) publishing in Anticancer Research have discovered that one’s risk of developing melanoma is inversely related to long-term smoking and exposure to UV light!
Which is to say, you’re less likely to get melanoma if you spend all day out in the sun [...]

SIRT6 and NF-kB link suggests aging is active process

Stanford researchers have revealed a link between two aging-related pathways, which will be published in the 9 January 2009 issue of Cell .
Researchers from Stanford University revealed today that they have found a link between SIRT6 and NF-kB – that the aging-related processes influenced by NF-kB are under the control of SIRT6, suggesting that aging [...]

Old drug Clioquinol may slow aging

An old gastrointestinal drug, Clioquinol, has been shown to inhibit the aging-associated protein CLK-1 and is showing promise for treating Alheimer’s, Parkinson’s, and Huntington’s diseases.
It’s always good when an old (and therefore out of patent) drug gets fresh life breathed into it, especially when it’s touted as a potential new anti-aging therapy. Clioquinol was used [...]

Beekeepers show anti-aging effects

A bright spark in Russia decided to investigate whether beekeepers appear young for their age on account of eating a lot of honey. They do!
Maybe it’s time to increase one’s honey intake!
Products of bee-keeping and prophylaxis of premature aging
Adv Gerontol. 2008;21(2):252-7. PMID: 18942370
Dubtsova EA, Kas’ianenko VI, Komissarenko IA, Lazebnik LB.
Natural bee honey is one [...]