‘Dermatology’ Archive

Results and reflections on doxycycline experiment

A little over a month ago I conducted a personal experiment where I took 25mg/day doxycycline hyclate in an effort to improve the quality of my skin by reducing collagen breakdown via the inhibition of Matrix-Metalloproteinases (MMPs).
For the duration of the experiment, I consumed approximately 25mg doxycycline in the morning on top of my usual [...]

Smoking and UV exposure reduce melanoma risk

In a strange twist, researchers from the Sunlight, Nutrition, and Health Research Center (SUNARC) publishing in Anticancer Research have discovered that one’s risk of developing melanoma is inversely related to long-term smoking and exposure to UV light!
Which is to say, you’re less likely to get melanoma if you spend all day out in the sun [...]

Green tea supplementation reduces skin cancer risk

Good news for green-tea drinkers and supplementers like me. The Journal of Investigative Dermatology reported a few days ago on the mechanism of the inhibition of UVB-induced skin tumor development.
The article is reasonably technical, but I’ll summarize the results here:
Green tea polyphenol (GTP) supplementation in mice prevents photocarcinogenesis (i.e., skin cancer). I’ve not mentioned this [...]

Topical protein C promotes wound healing

An article in the Archives of Dermatology reports that patients with chronic leg ulcers benefited from topical protein C treatment.
All study participants with recalcitrant leg ulcers saw rapidly improved healing following treatment with activated protein C.
The likely mechanism of action is activated protein C’s recognized ability to stimulate angiogenesis and reepithelialization and to inhibit inflammation.
What [...]