Some of you may be aware that the the antibiotic doxycycline hyclate has been found to possess anti-matrix metalloproteinase (MMP) activities. MMPs are the enzymes that break down connective tissue such as collagen, and their relative increase is thought to contribute to the development of wrinkles in aged skin.
This is because, while the ability to [...]

I came across this article today titled “Disruption of the Ang II type 1 receptor promotes longevity in mice”, which is available for free in PDF form for those interested in having a look.
Essentially, the researchers examined the effect of knocking out the Angiotensin (Ang) II type 1 receptor in a bunch of mice and [...]

An old gastrointestinal drug, Clioquinol, has been shown to inhibit the aging-associated protein CLK-1 and is showing promise for treating Alheimer’s, Parkinson’s, and Huntington’s diseases.
It’s always good when an old (and therefore out of patent) drug gets fresh life breathed into it, especially when it’s touted as a potential new anti-aging therapy. Clioquinol was used [...]

Researchers at Yale University have found a new substance that is released by the stomach following the consumption of fatty food. Suppressing appetite and causing weight-loss in rats and mice, this substance might lead to novel obesity treatments for humans in future.
The team, headed by Professor Gerald I. Shulman, investigated substances known as N-acylphosphatidylethanolamines, or [...]

Previously reported-on future experimental muscle drug MK-677 has been found to not help with Alzheimer’s progression despite stimulating production of IGF-I.
A study from the American Academy of Neurology reports that despite evidence that increased IGF-I helps reduce beta-amyloid plaques in the minds of mice, the IGF-I stimulating drug MK-677 did not help humans given the [...]